mixed material bibliography Arab Saudi University of Jeddah 2024 monographic March 2024 id Indonesia

Jurnal

ABSTRACT Background: Tetrazole-based derivatives and their electronic structures have displayed interesting antimicrobial activity. Methods: The tetrazole-based hybrids linked with thiazole, thiophene and thiadiazole ring systems have been synthesized through various chemical reactions. The computational method DFT/B3LYP has been utilized to calculate their electronic properties. The antimicrobial effectiveness was investigated against representative bacterial and fungal strains. Additionally, the synthesized derivatives binding interaction was stimulated by docking program against PDB ID: 4URO as a model of the ATP binding domain of S. aureus DNA Gyrase subunit B. Results: The structures of the synthesized tetrazole-based derivatives were confirmed by IR, NMR, and Mass spectroscopic data. The DFT/B3LYP method showed that the thiadiazole derivatives 9a–c had lower ΔEH-L than the thiophenes 7a–c and thiazoles 5a–c. The hybrids 5b, 5c, and 7b exhibited proper antibacterial activity against Gram’s +ve bacterial strains (S. aureus and S. pneumonia), while 9a displayed potent activity towards Gram’s -ve bacterial strains (S. typhimurium and E. coli). Meanwhile, derivatives 5a-b, 7a, 7c, and 9c showed good effectiveness towards fungal strain (C. albicans). Conclusion: The study provides valuable tetrazole core-linked heterocyclic rings and opens the door to further research on their electrical characteristics and applications. Tetrazoles and thiazoles have antibacterial prop- erties in pharmacological frameworks, making these hybrids potential lead molecules for drug development. The conclusion summarizes the data and suggests that the synthesized chemicals’ interaction with a particular protein domain suggests focused biological activity. DNA Gyrase Tetrazole-thiophene hybrids Docking DFT modelling PERPUSTAKAAN SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA REPOSITORY JIN178 Perpus.Akfarsam (Jurnal Farmasi Internasional) 615 SAU s March 2024 March_2024.jpeg.jpeg 2395 2026-07-21 07:43:07 2026-07-21 07:49:50 machine generated