Saudi Pharmaceutical Journal October 2023

Title	Saudi Pharmaceutical Journal October 2023
Edition	October 2023
Call Number
ISBN/ISSN
Author(s)
Subject(s)	Wound healing Azadirachta Indica Neem Hydrogel
Classification
Series Title
GMD	Jurnal
Language	Indonesia
Publisher	University of Jeddah
Publishing Year	2024
Publishing Place	Arab Saudi
Collation
Abstract/Notes	abstract Background & Objectives: Wound healing is the complex physiological process of replacing damaged cells or tissue layers. The neem (Azadirachta Indica) has a variety of biological activities, which may hasten the rate at which the wound healing mechanism occurs. Silk fibroin is a biomaterial that is reported for its tissue regeneration activity. So, the present study was designed to assess the effectiveness of a hydrogel comprising neem and silk fibroin biomaterials for the treatment of wounds. Methods: Topical neem hydrogels (N-HG) with and without silk fibroin (N-SFB-HG) were prepared using neem extract, silk fibroin, and guar gum, which act by entrapping the components by forming a gel. Evaluation tests such as Fourier transform infrared spectroscopy (FT-IR), visual emergence, pH, rheolog- ical behavior, spreading capacity, drug content, skin irritation, anti-microbial action, in vivo wound heal- ing activity, and stability were carried out. Results: The FT-IR results showed no chemical interaction between the constituents. The formed hydro- gels had pH values of 5.87 ± 0.3 for N-HG and 5.76 ± 0.2 for N-SFB-HG. The preferred topical gel viscosity was observed in the N-HG (54.2 ± 3.2cPs) and N-SFB-HG (59.9 ± 4.8cPs) formulations. The formulated hydrogels were sterile and did not irritate the skin. The in vivo wound healing investigation results reveal that the N-SF-HG treatment speeds up the regeneration of the injured area faster when compared to con- trol and N-HG treated groups. Interpretation & Conclusion: These results support the efficacy of the topical hydrogel formulation, includ- ing neem and silk fibroin. Therefore, the neem-silk fibroin hydrogel formulation is a therapeutically viable choice that, following necessary clinical research, might be utilized in novel formulations for managing chronic wounds.
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