mixed material bibliography Arab Saudi University of Jeddah 2024 monographic October 2023 id Indonesia

Jurnal

abstract Background & Objectives: Wound healing is the complex physiological process of replacing damaged cells or tissue layers. The neem (Azadirachta Indica) has a variety of biological activities, which may hasten the rate at which the wound healing mechanism occurs. Silk fibroin is a biomaterial that is reported for its tissue regeneration activity. So, the present study was designed to assess the effectiveness of a hydrogel comprising neem and silk fibroin biomaterials for the treatment of wounds. Methods: Topical neem hydrogels (N-HG) with and without silk fibroin (N-SFB-HG) were prepared using neem extract, silk fibroin, and guar gum, which act by entrapping the components by forming a gel. Evaluation tests such as Fourier transform infrared spectroscopy (FT-IR), visual emergence, pH, rheolog- ical behavior, spreading capacity, drug content, skin irritation, anti-microbial action, in vivo wound heal- ing activity, and stability were carried out. Results: The FT-IR results showed no chemical interaction between the constituents. The formed hydro- gels had pH values of 5.87 ± 0.3 for N-HG and 5.76 ± 0.2 for N-SFB-HG. The preferred topical gel viscosity was observed in the N-HG (54.2 ± 3.2cPs) and N-SFB-HG (59.9 ± 4.8cPs) formulations. The formulated hydrogels were sterile and did not irritate the skin. The in vivo wound healing investigation results reveal that the N-SF-HG treatment speeds up the regeneration of the injured area faster when compared to con- trol and N-HG treated groups. Interpretation & Conclusion: These results support the efficacy of the topical hydrogel formulation, includ- ing neem and silk fibroin. Therefore, the neem-silk fibroin hydrogel formulation is a therapeutically viable choice that, following necessary clinical research, might be utilized in novel formulations for managing chronic wounds. Wound healing Hydrogel Neem Azadirachta Indica PERPUSTAKAAN SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA REPOSITORY JIN173 Perpus.Akfarsam (Jurnal Farmasi Internasional) 615 SAU s October 2023 October_2023.jpeg.jpeg 2390 2026-07-20 10:26:34 2026-07-20 10:36:46 machine generated