Saudi Pharmaceutical Journal January 2023

Title	Saudi Pharmaceutical Journal January 2023
Edition	January 2023
Call Number
ISBN/ISSN
Author(s)
Subject(s)	Garlic Ginger Neomycin sulphate Nano-emulsions
Classification
Series Title
GMD	Jurnal
Language	Indonesia
Publisher	University of Jeddah
Publishing Year	2023
Publishing Place	Arab Saudi
Collation
Abstract/Notes	abstract Skin, largest organ of human, is directly exposed to environment and hence is prone to high rates of inju- ries and microbial infections. Over the passage of time these microbes have developed resistance to antibiotics making them ineffective especially in lower doses and hence, higher dosages or new drugs are required. The current study deals with designing of nano-emulsion (NE) formulations composed of garlic and ginger oils (0.1 %) with neomycin sulphate used in different ratios (0.001, 0.01 and 0.1 %) and combinations. The resulting NEs were characterized for droplet size (145–304 nm), zetapotential (-3.0–0.9 mV), refractive index (1.331–1.344), viscosity (1.10–1.23cP), transmittance (96–99 %), FT-IR and HPLC and found stable over a period of three months. All NEs were also found effective against both gram positive and negative bacterial strains i.e., B. spizizenii, S. aureus, E. coli and S. enterica as compared to pure neomycin sulphate (NS) used as control with highest activity recorded for NE-2 and NE-4 against all strains showing zone of inhibition in range of 22–30 mm and 21–19 mm, respectively. NEs were also tested using rabbit skin excision wound model which potentiates that all the NEs resulted in early recov- ery with 86–100 % wound healing achieved in 9 days as compared to NS ointment (71 %). The studies con- firmed that essential oils when used in combination with traditional drug can lead to much higher efficacies as compared to pure drugs.
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