Saudi Pharmaceutical Journal Agustus 2023

Title	Saudi Pharmaceutical Journal Agustus 2023
Edition	Agustus 2023
Call Number
ISBN/ISSN
Author(s)
Subject(s)	Oxidative stress Dodonaea viscosa Diabetes Streptozotocin
Classification
Series Title
GMD	Jurnal
Language	Indonesia
Publisher	University of Jeddah
Publishing Year	2023
Publishing Place	Arab Saudi
Collation
Abstract/Notes	abstract Previous investigations have shown that D. viscosa herbal extract is often used to treat a variety of dis- eases. Therefore, the purpose of this study was to investigate any additional potential impacts on rat liver and kidney damage induced by diabetes. Streptozotocin (STZ) (60 mg/kg/day) was given as a single dosage to cause type 1 diabetes. After then, diabetic rats received oral doses of D. viscosa for four weeks at 150 and 300 mg/kg/day. Blood, liver, and kidney tissues were collected at the end of the treatment and examined. Analysis was made of the serum lipid profile, liver, and kidney functions, as well as blood bio- chemistry. Moreover, the levels of tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), interleukin-1 beta (IL-1b), prostaglandin E-2 (PGE-2), and nitric oxide (NO) were estimated in serum. In liver and kid- ney samples, thiobarbituric acid reactive substances (TBARs) and reduced glutathione (GSH), as well as the pro-inflammatory cytokines and enzymatic activities of glutathione peroxidase (GPx), glutathione reeducates (GR), glutathione-S-transferase (GST), catalase (CAT), and superoxide dismutase (SOD) were analyzed. Histological changes in liver and kidney cross-sections were also observed. Our findings demonstrated that D. viscosa dramatically decreased pro-inflammatory indicators in blood, kidney, and liver tissues as well as blood glucose, and restored insulin levels, and lipid profiles. Additionally, it signif- icantly raises the antioxidant enzyme activity SOD, CAT, GPx, and GST, while significantly lowering TBARs levels. The above-mentioned biochemical changes that took place in tissues were further supported by histological alterations. These findings imply that D. viscosa protects against STZ-induced hyperglycemia, aberrant lipid synthesis, and oxidative stress and that these benefits may be mediated by interacting with various targets to increase the levels of antioxidant enzymes in the liver and kidneys. Its mode of action and safety for use as medicine against various metabolic problems caused by diabetes require more research.
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