Saudi Pharmaceutical Journal October 2022

Title	Saudi Pharmaceutical Journal October 2022
Edition	October 2022
Call Number
ISBN/ISSN
Author(s)
Subject(s)	antioxidant Agave marginate Alloxan-induced diabetes Open field test
Classification
Series Title
GMD	Jurnal
Language	Indonesia
Publisher
Publishing Year	2022
Publishing Place
Collation
Abstract/Notes	abstract Introduction: Diabetes mellitus causes hyperglycemia and associated complications to the brain. In cur- rent study, the traditionally reported remedial claims of Agave americana var. marginata has been scien- tifically investigated in diabetic rats. Methodology: The methanolic extract of leaves of Agave americana var. marginata (Aa.Cr) was character- ized for total phenols, flavonoids, and antioxidant potential through in-vitro testing. The rats chronically pre-treated with Aa.Cr (400 and 600 mg/kg) for 45 days were challenged with alloxan-induced hyper- glycemia. The dose-dependent effects of Aa.Cr on blood glucose levels and body weights were compared with diabetic rats using glibenclamide (0.6 mg/kg) as a standard. The animals were tested for diabetes- associated neurological comorbidities through behavioral and biochemical evaluation. Results: The phenols and flavonoids enriched Aa.Cr caused a significant dose-dependent hypoglycemic effect. Aa.Cr showed protection from comorbid anxiety, depression and cognitive impairment as com- pared to diabetic rats. The alanine aminotransferase, total cholesterol, triglycerides and low-density lipoprotein were prominently reduced, and high-density lipoprotein was increased in rats treated with Aa.Cr. Moreover, the oxidative stress in isolated brains was reduced by Aa.Cr. Conclusion: These findings suggest that Aa.Cr is enriched with antioxidant and anti-inflammatory phyto- constituents valuable for diabetes and related neurological complications.
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