Saudi Pharmaceutical Journal April 2022

Title	Saudi Pharmaceutical Journal April 2022
Edition	April 2022
Call Number
ISBN/ISSN
Author(s)
Subject(s)	Thymoquinone Nanocomposite High-pressure homogenizer
Classification
Series Title
GMD	Jurnal
Language	Indonesia
Publisher	University of Jeddah
Publishing Year	2022
Publishing Place	Arab Saudi
Collation
Abstract/Notes	abstract In this study, we formulated Thymoquinone-loaded nanocomposites (TQ-NCs) using high-pressure homogenizer without sodium tripolyphosphate. The TQ-NCs were characterized and their anti- inflammatory determined by the response of the LPS-stimulated macrophage RAW 264.7 cells in the pro- duction of nitric oxide, prostaglandin E2, tumor necrosis factor-a, interleukin-6, and interleukin-1b. The physicochemical properties of TQ-NC were determined using different machines. TQ was fully incorpo- rated in the highly thermal stable nanoparticles. The nanoparticles showed rapid release of TQ in the acidic medium of the gastric juice. In medium of pH 6.8, TQ-NC exhibited sustained release of TQ over a period of 100 h. The results suggest that TQ-NC nanoparticles have potential application as parenterally administered therapeutic compound. TQ-NC effectively reduce production of inflammatory cytokines by the LPS-stimulated RAW 264.7 cells, indicating that they have anti-inflammatory properties. In conclu- sion, TQ-NC nanoparticles have the characteristics of efficient carrier for TQ and an effective anti- inflammatory therapeutic compound.
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