mixed material bibliography 2025 monographic 1 March 2025 id Indonesia

Jurnal

ABSTRACT Triple-negative breast cancer (TNBC) presents with resistance phenotypes to certain therapies, such as cisplatin, often requiring higher dosing, with associated acquired tumor resistance, renal toxicity, and variable patient responses. A self-emulsifying drug delivery (SEDD) formulation approach was proposed to overcome the limi- tations of cisplatin in TNBC, focusing on improving intracellular cisplatin and control siRNA uptake as a proof-of- principle of dual drug delivery. Four SEDD formulations were prepared and optimized for cisplatin (o/w) emulsion and FITC-siRNA (w/o) emulsion using pseudo-ternary phase diagrams to facilitate the formation of water-in-oil-water (w/o/w) emulsions. Formulations were characterized by size, polydispersity (PDI), and sur- face charge and tested in vitro. Cellular uptake via triplex staining of drug-loaded SEDDs was investigated. SEDDs showed enhanced internalization and promoted selective TNBC cellular uptake. The current study is a proof-of- principle for the successful co-delivery of cisplatin (small molecule) and siRNA (large molecule) via the SEDDs platform. apoptosis Triple-negative breast cancer (TNBC) drug delivery PERPUSTAKAAN SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA REPOSITORY JIN0144 Perpus.Akfarsam (Jurnal Farmasi Internasional) 615 ASI 1 March 2025 1_March_2025.jpeg.jpeg 2361 2026-07-14 07:53:13 2026-07-14 08:03:53 machine generated