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<title>European Journal of Pharmaceutical Sciences 1 May 2024</title>
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<dateIssued>2024</dateIssued>
<issuance>monographic</issuance>
<edition>1 May 2024</edition>
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<languageTerm type="text">Indonesia</languageTerm>
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<note>ABSTRACT
Over the recent decades, stem cell-based therapies have been considered as a beneficial approach for the
treatment of various diseases. In these types of therapies, the stem cells and their products are used as treating
agents. Despite the helpful efficacy of stem cell-based therapies, there may be challenges. Oxidative stress (OS) is
one of these challenges that can affect the therapeutic properties of stem cells. Therefore, it seems that employing
strategies for the reduction of OS in combination with stem cell therapy can lead to better results of these
therapies. Based on the available evidence, antioxidant therapy and photobiomodulation (PBM) are strategies
that can regulate the OS in the cells. Antioxidant therapy is a method in which various antioxidants are used in
the therapeutic processes. PBM is also the clinical application of light that gained importance in medicine.
Antioxidants and PBM can regulate OS by the effect on mitochondria as an important source of OS in the cells.
Considering the importance of OS in pathologic pathways and its effect on the treatment outcomes of stem cells,
in the present review first the stem cell therapy and effects of OS on this type of therapy are summarized. Then,

antioxidant therapy and PBM as approaches for reducing OS with a focus on mitochondrial function are dis-
cussed. Also, a novel combination treatment with the hope of achieving better and more stable outcomes in the treatment process of diseases is proposed.</note>
<subject authority=""><topic>Antioxidants</topic></subject>
<subject authority=""><topic>Oxidative stress</topic></subject>
<subject authority=""><topic>Stem cell therapy</topic></subject>
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