mixed material bibliography 2024 monographic 1 July 2024 id Indonesia

Jurnal

ABSTRACT Central nervous system (CNS) diseases are among the major health problems. However, blood-brain barrier (BBB) makes traditional oral and intravenous delivery of CNS drugs inefficient. The unique direct connection between the nose and the brain makes nasal administration a great potential advantage in CNS drugs delivery. However, nasal mucociliary clearance (NMCC) limits the development of drug delivery systems. Appropriate nasal gel viscosity alleviates NMCC to a certain extent, gels based on gellan gum, chitosan, carbomer, cellulose and poloxamer have been widely reported. However, nasal gel formulation design and key properties for alle- viating NMCC have not been clearly discussed. This article summarizes gel formulations of different polymers in existing nasal gel systems, and attempts to provide a basis for researchers to conduct in-depth research on the key characteristics of gel matrix against NMCC. Drug delivery system Prescription design Nasal administration PERPUSTAKAAN SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA REPOSITORY JIN0137 Perpus.Akfarsam (Jurnal Farmasi Internasional) 615 ASI 1 July 2024 1_July_2024.jpeg.jpeg 2354 2026-07-13 08:36:11 2026-07-13 08:44:20 machine generated