European Journal of Pharmaceutical Sciences 1 January 2024

Title	European Journal of Pharmaceutical Sciences 1 January 2024
Edition	1 January 2024
Call Number
ISBN/ISSN
Author(s)
Subject(s)	Nasal administration Prescription design Drug delivery system
Classification
Series Title
GMD	Jurnal
Language	Indonesia
Publisher
Publishing Year	2024
Publishing Place
Collation
Abstract/Notes	ABSTRACT Central nervous system (CNS) diseases are among the major health problems. However, blood-brain barrier (BBB) makes traditional oral and intravenous delivery of CNS drugs inefficient. The unique direct connection between the nose and the brain makes nasal administration a great potential advantage in CNS drugs delivery. However, nasal mucociliary clearance (NMCC) limits the development of drug delivery systems. Appropriate nasal gel viscosity alleviates NMCC to a certain extent, gels based on gellan gum, chitosan, carbomer, cellulose and poloxamer have been widely reported. However, nasal gel formulation design and key properties for alle- viating NMCC have not been clearly discussed. This article summarizes gel formulations of different polymers in existing nasal gel systems, and attempts to provide a basis for researchers to conduct in-depth research on the key characteristics of gel matrix against NMCC.
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