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<title>European Journal of Pharmaceutical Sciences 1 September 2023</title>
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<dateIssued>2023</dateIssued>
<issuance>monographic</issuance>
<edition>1 September 2023</edition>
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<languageTerm type="text">Indonesia</languageTerm>
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<note>ABSTRACT

Microbial resistance has increased in recent decades as a result of the extensive and indiscriminate use of an-
tibiotics. The World Health Organization listed antimicrobial resistance as one of ten major global public health

threats in 2021. In particular, six major bacterial pathogens, including third-generation cephalosporin-resistant

Escherichia coli, methicillin-resistant Staphylococcus aureus, carbapenem-resistant Acinetobacter baumannii, Kleb-
siella pneumoniae, Streptococcus pneumoniae, and Pseudomonas aeruginosa, were found to have the highest

resistance-related death rates in 2019. To respond to this urgent call, the creation of new pharmaceutical

technologies based on nanoscience and drug delivery systems appears to be the promising strategy against mi-
crobial resistance in light of recent advancements, particularly the new knowledge of medicinal biology.

Nanomaterials are often defined as substances having sizes between 1 and 100 nm. If the material is used on a

small scale; its properties significantly change. They come in a variety of sizes and forms to help provide dis-
tinguishing characteristics for a wide range of functions. The field of health sciences has demonstrated a strong

interest in numerous nanotechnology applications. Therefore, in this review, prospective nanotechnology-based
therapeutics for the management of bacterial infections with multiple medication resistance are critically
examined. Recent developments in these innovative treatment techniques are described, with an emphasis on preclinical, clinical, and combinatorial approaches.</note>
<subject authority=""><topic>bacterial infection</topic></subject>
<subject authority=""><topic>Nanotechnology</topic></subject>
<subject authority=""><topic>Microbial resistance</topic></subject>
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<sublocation>Perpus.Akfarsam (Jurnal Farmasi Internasional)</sublocation>
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