European Journal of Pharmaceutical Sciences 1 March 2023

Title	European Journal of Pharmaceutical Sciences 1 March 2023
Edition	1 March 2023
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ISBN/ISSN
Author(s)
Subject(s)	Oral proteins and peptides Enhanced mucosal delivery Mucosal vaccines
Classification
Series Title
GMD	Jurnal
Language	Indonesia
Publisher
Publishing Year	2023
Publishing Place
Collation
Abstract/Notes	ABSTRACT Therapeutic proteins and peptides (TPPs) are increasingly favoured above small drug molecules due to their high specificity to the site of action and reduced adverse effects resulting in increased use of these agents for medical treatments and therapies. Consequently, there is a need to formulate TPPs in dosage forms that are accessible and suitable for a wide range of patient groups as the use of TPPs becomes increasingly prevalent in healthcare settings worldwide. Orally disintegrating dosage forms (ODDF) are formulations that can ensure easy-to- administer medication to a wider patient population including paediatrics, geriatrics and people in low- resource countries. There are many challenges involved in developing suitable pharmaceutical strategies to protect TPPs during formulation and manufacturing, as well as storage, and maintenance of a cold-chain during transportation. This review will discuss advances being made in the research and development of pharmaceutical and manufacturing strategies used to incorporate various TPPs into ODDF systems.
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