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<title>European Journal of Pharmaceutical Sciences 1 March 2023</title>
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<dateIssued>2023</dateIssued>
<issuance>monographic</issuance>
<edition>1 March 2023</edition>
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<languageTerm type="text">Indonesia</languageTerm>
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<note>ABSTRACT
Therapeutic proteins and peptides (TPPs) are increasingly favoured above small drug molecules due to their high
specificity to the site of action and reduced adverse effects resulting in increased use of these agents for medical
treatments and therapies. Consequently, there is a need to formulate TPPs in dosage forms that are accessible and
suitable for a wide range of patient groups as the use of TPPs becomes increasingly prevalent in healthcare

settings worldwide. Orally disintegrating dosage forms (ODDF) are formulations that can ensure easy-to-
administer medication to a wider patient population including paediatrics, geriatrics and people in low-
resource countries. There are many challenges involved in developing suitable pharmaceutical strategies to

protect TPPs during formulation and manufacturing, as well as storage, and maintenance of a cold-chain during
transportation. This review will discuss advances being made in the research and development of pharmaceutical
and manufacturing strategies used to incorporate various TPPs into ODDF systems.</note>
<subject authority=""><topic>Mucosal vaccines</topic></subject>
<subject authority=""><topic>Enhanced mucosal delivery</topic></subject>
<subject authority=""><topic>Oral proteins and peptides</topic></subject>
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<sublocation>Perpus.Akfarsam (Jurnal Farmasi Internasional)</sublocation>
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