Asian Journal of Pharmaceutical Sciences Volume 20, Issue 5 2025

Title	Asian Journal of Pharmaceutical Sciences Volume 20, Issue 5 2025
Edition	Volume 20, Issue 5 2025
Call Number
ISBN/ISSN
Author(s)
Subject(s)	Extracellular vesicles Immunotherapy Exosomes
Classification
Series Title
GMD	Jurnal
Language	Indonesia
Publisher	China Medical University
Publishing Year	2025
Publishing Place	China
Collation
Abstract/Notes	a b s t r a c t Cancer is a major global concern due to its high mortality rate. Tumor immunotherapy has revolutionized cancer treatment. However, low response rates and immune-related complications remain challenges. Extracellular vesicles (EVs), including exosomes, have emerged as promising therapeutic tools for various pathological conditions, especially cancer. Evidence indicates that changes in the quantity and composition of EVs can influence the immunosuppressive tumor microenvironment, potentially affecting the effectiveness of immunotherapy. Exploiting EVs for immune sensitization has generated significant clinical interest. This review provides an in-depth understanding of the origin of EVs, their therapeutic applications (such as drug delivery nanoplatforms and cancer immunotherapies, including vaccines), diagnostic potential as tumor biomarkers, ongoing EV-based clinicaltrials, and the challenges encountered in EV-based cancer immunotherapy.
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