mixed material bibliography China China Medical University 2025 monographic Volume 20, Issue 4 2025 id Indonesia

Jurnal

a b s t r a c t Immunotherapy has transformed cancer treatment, marked by the approval of numerous antibody-based drugs. However,the limitations of antibodies in pharmacokinetics including long half-lives, limited oral bioavailability and immunogenicity, have prompted the pursuit of small molecule-based immunotherapy. Traditional drug discovery strategies, which focus on blocking protein activity through inhibitors, face persistent hurdles, such as reliance on accessible binding pockets, poor selectivity, and the emergence of drug resistance. Targeted protein degradation (TPD) technologies have emerged as powerful tools to address these limitations, offering significant therapeutic advantages over conventional inhibition strategies, particularly for historically ’’undruggable’’ targets. In recent years, small molecule-based protein degraders have rapidly advanced in cancer immunotherapy. In this review, we highlight recent progress in TPD-driven small-molecule drug discovery and summarize the application of these technologies in cancer immunotherapy, including degraders targeting PD-1/PD-L1, chemokine receptors, IDO1, AhR, and others. Cancer immunotherapy Degraders Small molecules PERPUSTAKAAN SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA REPOSITORY JIN0127 Perpus.Akfarsam (Jurnal Farmasi Internasional) 615 ASI Volume 20, Issue 4 2025 Volume_20%2C_Issue_4.jpeg.jpeg 2344 2026-07-10 12:31:32 2026-07-10 12:57:06 machine generated