Indonesia Journal of Pharmacy Vol 36 No 3 2025

Title	Indonesia Journal of Pharmacy Vol 36 No 3 2025
Edition	Vol 36 No 3 2025
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ISBN/ISSN
Author(s)
Subject(s)	Acne Lentinula edodes Auricularia Agaricus bisporus
Classification
Series Title
GMD	Jurnal
Language	Indonesia
Publisher	Universitas Gadjah Mada
Publishing Year	2025
Publishing Place	Jogjakarta
Collation
Abstract/Notes	Acne is a common chronic inflammatory skin disease in which the skin pores are clogged with oil and dead skin cells. One of the factors that influence the appearance of acne is the colonization of acne-causing bacteria. Mushrooms are now offered as an alternative and complementary therapy for acne. This review aimed to evaluate natural sources of fungal origin for preventing and treating acne caused by bacteria. This review presents the application of several mushrooms in the management of acne. Electronic databases such as Web of Science, PubMed, Scopus, and Google Scholar were reviewed to identify the anti-acne effects of mushrooms. Based on the results of a literature review, it was proven that the methanol extract and hexane extract of the fungus Auricularia auricula Judei showed activity against Staphylococcus aureus bacteria at a concentration of 100 mg/mL with inhibition zones of 25.3 mm and 22 mm respectively with an Minimum Inhibitory Concentration (MIC) of 3.125 μg/mL and 6.25 μg/mL. Methanol extract and hexane extract of the fungus Auricularia polytricha showed activity against Staphylococcus aureus bacteria at a concentration of 100 mg/mL with inhibition zones of 28.6 mm and 25.3 mm respectively with the same MIC value of 0.78 μg/mL. Shiitake mushroom ethanol extract showed activity against Propionibacterium acnes bacteria at a concentration of 25 mg/mL with zone of inhibition of 13.4 mm. while n hexane and ethyl acetate extracts had MIC values of 256 μg/mL against Propionibacterium acnes, Staphylococcus aureus and Staphylococcus epidermidis. Agaricus bisporus methanol extract showed activity against Bacillus subtilis bacteria at a concentration of 200 μg/mL with an inhibition zone of 19 mm. In conclusion, mushroom can be used to manage acne caused by bacteria. Keywords: Acne, Lentinula edodes, Auricularia, Agaricus bisporus, Propionibacterium acnes
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