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<title>Indonesia Journal of Pharmacy Vol 36 No 3 2025</title>
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<place><placeTerm type="text">Jogjakarta</placeTerm></place>
<publisher>Universitas Gadjah Mada</publisher>
<dateIssued>2025</dateIssued>
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<edition>Vol 36 No 3 2025</edition>
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<languageTerm type="text">Indonesia</languageTerm>
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<note>Acne is a common chronic inflammatory skin disease in which the skin
pores are clogged with oil and dead skin cells. One of the factors that influence
the appearance of acne is the colonization of acne-causing bacteria.
Mushrooms are now offered as an alternative and complementary therapy for
acne. This review aimed to evaluate natural sources of fungal origin for
preventing and treating acne caused by bacteria. This review presents the
application of several mushrooms in the management of acne. Electronic
databases such as Web of Science, PubMed, Scopus, and Google Scholar were
reviewed to identify the anti-acne effects of mushrooms. Based on the results
of a literature review, it was proven that the methanol extract and hexane
extract of the fungus Auricularia auricula Judei showed activity against
Staphylococcus aureus bacteria at a concentration of 100 mg/mL with
inhibition zones of 25.3 mm and 22 mm respectively with an Minimum
Inhibitory Concentration (MIC) of 3.125 &mu;g/mL and 6.25 &mu;g/mL. Methanol
extract and hexane extract of the fungus Auricularia polytricha showed
activity against Staphylococcus aureus bacteria at a concentration of 100
mg/mL with inhibition zones of 28.6 mm and 25.3 mm respectively with the
same MIC value of 0.78 &mu;g/mL. Shiitake mushroom ethanol extract showed
activity against Propionibacterium acnes bacteria at a concentration of 25
mg/mL with zone of inhibition of 13.4 mm. while n hexane and ethyl acetate
extracts had MIC values of 256 &mu;g/mL against Propionibacterium acnes,
Staphylococcus aureus and Staphylococcus epidermidis. Agaricus bisporus
methanol extract showed activity against Bacillus subtilis bacteria at a
concentration of 200 &mu;g/mL with an inhibition zone of 19 mm. In conclusion,
mushroom can be used to manage acne caused by bacteria.

Keywords: Acne, Lentinula edodes, Auricularia, Agaricus bisporus,
Propionibacterium acnes</note>
<subject authority=""><topic>Agaricus bisporus</topic></subject>
<subject authority=""><topic>Auricularia</topic></subject>
<subject authority=""><topic>Lentinula edodes</topic></subject>
<subject authority=""><topic>Acne</topic></subject>
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