The American Journal of Clinical Nutrition Volume 154 Issue 1 2024

Title	The American Journal of Clinical Nutrition Volume 154 Issue 1 2024
Edition	Volume 154 Issue 1 2024
Call Number
ISBN/ISSN
Author(s)
Subject(s)	Clinical Nutrition
Classification
Series Title
GMD	Karya Tulis Ilmiah
Language	Indonesia
Publisher	2024
Publishing Year
Publishing Place	Amerika
Collation
Abstract/Notes	Background: Increased serum urate (SU) and hyperuricemia (HU) are associated with chronic noncommunicable diseases and mortality. SU concentrations are affected by several factors, including diet, and are expected to rise with age. We investigated whether the Dietary Ap- proaches to Stop Hypertension (DASH) diet alter this trend. Objective: The objective was to assess whether adherence to the DASH diet predicts a longitudinal change in SU concentrations and risk of HU in 8 y of follow-up. Methods: Longitudinal analyses using baseline (2008–2010, aged 35–74 y), second (2012–2014), and third (2016–2018) visits data from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The inclusion criteria were having complete food frequency questionnaire (FFQ) and urinary sodium measurement, in addition to having SU measurement at the 1st visit and at least 1 of the 2 follow-up visits. For the HU incidence analyses, participants had also to be free from HU at baseline. The final samples included 12575 individuals for the SU change analyses and 10549 for the HU incidence analyses. Adherence to DASH diet was assessed as continuous value. HU was defined as SU>6.8 mg/dL and/or urate-lowering therapy use. Mixed-effect linear and Poisson regressions (incidence rate ratio [IRR] and 95% confidence interval [CI]) were used in the analyses, adjusted for confounders. Results: The mean age was 51.4 (8.7) y, and 55.4% were females. SU means (standard deviation) were 5.4 (1.4) at 1st visit, 5.2 (1.4) at 2nd visit, and 5.1(1.3) mg/dL at 3rd visit. The HU incidence rate was 8.87 per 1000 person-y. Each additional point in adherence to the DASH diet accelerated SU decline (P< 0.01) and lowered the incidence of HU by 4.3% (IRR: 0.957; 95% CI: 0.938,0.977) in adjusted model. Conclusion: The present study findings reinforce the importance of encouraging the DASH diet as a healthy dietary pattern to control and reduce the SU concentrations and risk of HU. Keywords: DASH, urate, uric acid, cohort study, ELSA-Brasil
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