mixed material bibliography marmara University 2024 monographic 2024 , Vol 28 , Issue 3 id Indonesia

Karya Tulis Ilmiah

ABSTRACT: The combination of entecavir (ETV) and tenofovir (TEV), nucleos(t)ide analogs (NUCs), is advised as first- line treatment for people suffering from multidrug-resistant hepatitis B due to their favorable safety profile, low side- effect rate, and high genetic barrier. This study reports the fabrication of a novel cross-linked ethylenediamine sulfonamide polymer resin (EDASP) and graphene (Gr)-modified carbon paste electrodes (CPE) for the simultaneous determination of the anti-HBV drugs ETV and TEV in bulk and dosage form by differential pulse voltammetry (DPV). The electrodes were specified through cyclic voltammetry, Fourier transform infrared (FTIR), scanning electron microscopy (SEM), and the analytical parameters were optimized. The findings indicate that both drugs displayed clear oxidation peaks on the Gr-CPE and EDASP-CPE electrodes at pH 4.5 and 4.0, respectively, in the Britton-Robinson buffer. The linear dynamic range of ETV and TEV was determined between 1μM and 250μM on both working electrodes by DPV. The limit of detection (LOD) and limit of quantification (LOQ) for ETV were 0.2μM and 0.6μM, respectively, on Gr-CPE. The LOD and LOQ for TEV were 0.2μM and 0.7μM, respectively. The novel EDASP-CPE exhibited improved sensitivity with LOD and LOQ for ETV of 0.2μM and 0.5μM, respectively. The LOD and LOQ for TEV on EDASP CPE were 0.2μM and 0.7μM, respectively. The proposed method was successfully applied to the simultaneous determination of ETV and TEV in a commercial tablet dosage form, exhibiting good accuracy and precision. The results highlight the potential of the novel cross-linked ethylenediamine sulfonamide polymer resin-modified carbon paste electrode for the simultaneous determination of anti-HBV drugs in dosage form by differential pulse voltammetry. KEYWORDS: Tenofovir, entecavir, ethylenediamine sulfonamide polymer resin, graphene, modified carbon paste electrode, voltammetry, pharmaceutical preparation. voltammetry graphene ethylenediamine sulfonamide polymer resin entecavir Tenofovir PERPUSTAKAAN SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA REPOSITORY JIN0111 Perpus.Akfarsam (Jurnal Internasioan) 615 MAR b Marmara Pharmaceutical Journal of Research in Pharmacy Journal of Research in Pharmacy 2024 , Vol 28 , Issue 3 2031 2025-01-30 14:00:40 2025-01-30 14:03:55 machine generated