Indonesia Journal of Pharmacy Vol 35 No 1 2024

Title	Indonesia Journal of Pharmacy Vol 35 No 1 2024
Edition	Vol 35 No 1 2024
Call Number
ISBN/ISSN
Author(s)
Subject(s)	Genus Leea Pharmacological activity Toxicity
Classification
Series Title
GMD	Karya Tulis Ilmiah
Language	Indonesia
Publisher	Universitas Gadjah Mada
Publishing Year	2023
Publishing Place	Jogjakarta
Collation
Abstract/Notes	The genus Leea is widely recognized as a valuable source of medicinal plants, and half of its species are traditionally used to treat various diseases. According to previous studies, it also has significant potential for yielding molecules that can serve as drugs or lead compounds in the discovery of pharmaceutical products. Therefore, this review aimed to identify research gaps in the development of plant-based medicines from the genus Leea. The procedures comprised extracting data from 108 articles, which explored plants from the genus Leea and were published from 1997 to 2022. The articles reviewed consisted of data on pharmacological activity, isolated compounds, and toxicity potential. The results showed that among the 36 species in the genus, L. indica, L. macrophylla, L. asiatica, L. aequata, L. aculeata, L. guinensis, and L. rubra were often used in traditional medicine, leading to their frequent exploration in previous reports. A total of 66 compounds had been isolated, with 46 being known to have pharmacological activity. In addition, the dominant pharmacological activities of these compounds included antioxidant, antimicrobial, anti-inflammatory, and anticancer properties. The acute toxicity test results showed that the extract of plants from the genus was often categorized as not toxic at a dose of up to 2 g/kg BW. Based on the various pharmacological activities of the isolates and extracts, as well as the low toxicity potential, the genus Leea has the potential to be explored for the development of new drugs. Keywords: Genus Leea, Pharmacological activity, Toxicity
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