Indonesia Journal of Pharmacy Vol 33 No 4 2022

Title	Indonesia Journal of Pharmacy Vol 33 No 4 2022
Edition	Vol 33 No 4 2022
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ISBN/ISSN
Author(s)
Subject(s)	Curcumin analogues anti-Alzheimer’s candidates cell-based assay transgenic mice
Classification
Series Title
GMD	Karya Tulis Ilmiah
Language	Indonesia
Publisher	Universitas Gadjah Mada
Publishing Year	2022
Publishing Place	Jogjakarta
Collation
Abstract/Notes	Alzheimer’s disease (AD) is a neurological illness that is known to cause a wide range of cognitive symptoms linked to amyloid plaque deposition, neurofibrillary tangles, oxidative stress, and neuronal death in the whole brain. Curcumin has shown promising efficacy in preclinical studies for AD treatment. However, it failed to exhibit expected clinical outcomes in clinical studies. Besides, this molecule was found to have low stability, solubility, and bioavailability properties. Hence, scientists have synthesized several curcumin analogues in order to improve their bioavailability and biological activity. In this narrative review, we aim to discuss the development of curcumin analogue synthesis published in 2016–2021 and its efficacy as an anti-Alzheimer's candidate through in vitro, cell-based, and in vivo studies. PubMed and Scopus database were searched using the keywords “curcumin” AND “analogues” OR “analogs” AND “Alzheimer's”to find relevant studies. In our review, we included 16 eligible journal articles to discuss. In total, 15 curcumin analogues exhibited promising efficacy in preclinical studies and are found suitable for anti-Alzheimer’s candidates. Further studies should explore curcumin analogues’ effectiveness in other AD sub- pathologies as well as its pharmacokinetic profile and ability to achieve target action in the brain. Keywords: Curcumin analogues, anti-Alzheimer’s candidates, Aβ biosynthesis, cell-based assay, transgenic mice
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