Jurnal Ilmu Kefarmasian Indonesia Vol 20 No 1 2022

Title	Jurnal Ilmu Kefarmasian Indonesia Vol 20 No 1 2022
Edition	Vol 20 No 1 2022
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ISBN/ISSN
Author(s)
Subject(s)	propofol Fentanyl midazolam side effect general anesthesia
Classification
Series Title
GMD	Karya Tulis Ilmiah
Language	Indonesia
Publisher	Universitas Pancasila
Publishing Year	2022
Publishing Place	Jogjakarta
Collation
Abstract/Notes	Abstract: Propofol is one of the most commonly used intravenous drugs employed to induce and maintain general anesthesia. The eff ective induction dose of propofol is 1.0-2.5 mg/kg IV caused hemodynamic instability signifi cant as hypotension. Stability hemodynamic in used propofol can optimized with midazolam-fentanyl. The aims of this study was to determine the comparison of side eff ects propofol- fentanyl and propofol-fentanyl-midazolam in patient undergoing elective surgery with parameter of blood pressure, pulse, respiratory rate (RR). This study was a observational with prospective method in 60 patients undergoing elective surgery with physical status ASA I-II conducted in the period of April to July 2019. The result showed the induction anesthesia used of propofol-fentanyl caused decreased on systolic blood pressure 17.2±3 mmHg, diastolic blood pressure 5.3±1.6 mmHg, pulse 3.9±1.5 beats/ minute, and RR 1.4±0.01 breaths/minute. The induction anesthesia used of propofol-fentanyl-midazolam caused decreased on systolic blood pressure 11.8±0.4 mmHg, diastolic blood preasure 4.2±0.4 mmHg, pulse value 5.0±0.9 beats/minute, and RR 2.8±0.9 breaths/minute. Side eff ects in the form of blood pressure, pulse and respiratory rate from the administration of the combination of propofol-fentanyl and propofol-fentanyl-midazolam were not signifi cantly diff erent. Keywords: propofol, fentanyl, midazolam, side eff ect, general anesthesia.
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