mixed material bibliography Jogjakarta Universitas Pancasila 2022 monographic Vol 20 No 1 2022 id Indonesia

Karya Tulis Ilmiah

Abstract: Propofol is one of the most commonly used intravenous drugs employed to induce and maintain general anesthesia. The eff ective induction dose of propofol is 1.0-2.5 mg/kg IV caused hemodynamic instability signifi cant as hypotension. Stability hemodynamic in used propofol can optimized with midazolam-fentanyl. The aims of this study was to determine the comparison of side eff ects propofol- fentanyl and propofol-fentanyl-midazolam in patient undergoing elective surgery with parameter of blood pressure, pulse, respiratory rate (RR). This study was a observational with prospective method in 60 patients undergoing elective surgery with physical status ASA I-II conducted in the period of April to July 2019. The result showed the induction anesthesia used of propofol-fentanyl caused decreased on systolic blood pressure 17.2±3 mmHg, diastolic blood pressure 5.3±1.6 mmHg, pulse 3.9±1.5 beats/ minute, and RR 1.4±0.01 breaths/minute. The induction anesthesia used of propofol-fentanyl-midazolam caused decreased on systolic blood pressure 11.8±0.4 mmHg, diastolic blood preasure 4.2±0.4 mmHg, pulse value 5.0±0.9 beats/minute, and RR 2.8±0.9 breaths/minute. Side eff ects in the form of blood pressure, pulse and respiratory rate from the administration of the combination of propofol-fentanyl and propofol-fentanyl-midazolam were not signifi cantly diff erent. Keywords: propofol, fentanyl, midazolam, side eff ect, general anesthesia. side effect midazolam Fentanyl propofol general anesthesia PERPUSTAKAAN SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA REPOSITORY JN0314 Perpus.Akfarsam 051 JUR j Jurnal Ilmu Kefarmasian Indonesia Vol 20 No 1 2022 1966 2025-01-02 09:48:04 2025-01-02 09:55:17 machine generated