Tropical Journal of Natural Product Research Vol. 5(6) pp 988-1165 June 2021

Title	Tropical Journal of Natural Product Research Vol. 5(6) pp 988-1165 June 2021
Edition	Vol. 5(6) pp 988-1165 June 2021
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GMD	Karya Tulis Ilmiah
Language	Indonesia
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Abstract/Notes	Eugenol compounds contain several functional groups, namely allyl (-CH2-CH = CH2), phenol (OH) and methoxy (-OCH3). These groups allow eugenol to become the basis for the synthesis of various other compounds of higher value, such as isoeugenol and methyl eugenol. Eugenol compounds and their derivatives have numerous benefits in various industries, such as the pharmaceutical, cosmetic and other chemical industries. Metabolite profiling is a technique that analyses all substances detected in the sample used and identifies certain metabolites, however, there has been no review regarding the method of profiling eugenol compounds in various families. For this purpose, literature searches such as PubMed, ScienceDirect, Wiley, Google and other journal publications were conducted. Several studies related to eugenol profiling reported in the Piperaceae, Myrtaceae, Lauraceae and Myristicaceae families found the highest level of eugenol is in the range 83.6%. The methods used for profiling eugenol compounds are reported as thin-layer chromatography (TLC), gas chromatography-mass spectroscopy (GC-MS) and liquid chromatography-mass spectroscopy/mass spectroscopy (LC-MS/MS). In this review, profiling of eugenol compounds is best performed by sample preparation using distillation techniques followed by GC-MS analysis. Keywords: Metabolite profiling, Eugenol, GC-MS, Distillation.
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