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<title>Tropical Journal of Natural Product Research Vol. 5(6) pp 988-1165 June 2021</title>
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<edition>Vol. 5(6) pp 988-1165 June 2021</edition>
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<note>Eugenol compounds contain several functional groups, namely allyl (-CH2-CH = CH2), phenol
(OH) and methoxy (-OCH3). These groups allow eugenol to become the basis for the synthesis
of various other compounds of higher value, such as isoeugenol and methyl eugenol. Eugenol
compounds and their derivatives have numerous benefits in various industries, such as the
pharmaceutical, cosmetic and other chemical industries. Metabolite profiling is a technique that
analyses all substances detected in the sample used and identifies certain metabolites, however,
there has been no review regarding the method of profiling eugenol compounds in various
families. For this purpose, literature searches such as PubMed, ScienceDirect, Wiley, Google
and other journal publications were conducted. Several studies related to eugenol profiling
reported in the Piperaceae, Myrtaceae, Lauraceae and Myristicaceae families found the highest
level of eugenol is in the range 83.6%. The methods used for profiling eugenol compounds are
reported as thin-layer chromatography (TLC), gas chromatography-mass spectroscopy (GC-MS)
and liquid chromatography-mass spectroscopy/mass spectroscopy (LC-MS/MS).
In this review, profiling of eugenol compounds is best performed by sample preparation using
distillation techniques followed by GC-MS analysis.
Keywords: Metabolite profiling, Eugenol, GC-MS, Distillation.</note>
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