Tropical Journal of Natural Product Research Vol. 6(1) pp 1-170 January 2022

Title	Tropical Journal of Natural Product Research Vol. 6(1) pp 1-170 January 2022
Edition	Vol. 6(1) pp 1-170 January 2022
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GMD	Karya Tulis Ilmiah
Language	Indonesia
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Abstract/Notes	Flavonoids are plant secondary metabolites that are well-known for their bioactivities. In this article, the chemistry, plant sources, bioactivities and structure-activity relationships of acacetin (ACT) and chrysoeriol (CSE) are reviewed. Of these two flavones, only ACT has been reviewed but not CSE. Sources of information cited were from Google Scholar, PubMed, PubMed Central, Science Direct, Web of Science, J-Stage, PubChem and Directory of Open Access Journals (DOAJ). The criteria used for selection of articles are based on topics rather than period of coverage, although recent references accord higher priority. Flavones, a class of flavonoids, have a C2–C3 double bond and a 4-carbonyl group but lack the C3 hydroxyl group at ring C. ACT and CSE are lesser-known methylated flavones with hydroxyl groups at C5 and C7 of ring A. The methoxy group of ACT is at C4' while that of CSE is at C3'. Found in many plant species, ACT and CSE have generated much research interest because of their diverse pharmacological activities, notably, their anti-cancer properties. The anti-cancer effects and molecular mechanisms of ACT towards lung, liver, gastric, prostate, breast and squamous cancer cells including leukaemia have been reported. Studies have shown that CSE inhibited breast, lung and pancreatic cancer cells including myeloma. Other bioactivities and structure-activity relationships of ACT and CSE are also briefly mentioned. Some areas for further research are suggested. Keywords: Acacetin, Chrysoeriol, Methylated Flavones, Cytotoxicity, Structure-Activity Relationships.
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