Marmara Pharmaceutical Journal of Research in Pharmacy Journal of Research in Pharmacy 2020 , Vol 24 Issue 2

Title	Marmara Pharmaceutical Journal of Research in Pharmacy Journal of Research in Pharmacy 2020 , Vol 24 Issue 2
Edition	Vol 24 Issue 2
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GMD	Karya Tulis Ilmiah
Language	Indonesia
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Abstract/Notes	ABSTRACT: The oral hypoglycaemic agents as well as injectable insulin does not significantly alter the oxidative stress in the diabetes mellitus patients. Being an antioxidant Vitamin C (ascorbic acid) might help in tackling the adversities of reactive oxygen species. A randomized placebo controlled study was carried out with parallel assignment of both the test group and control group of patients. The intervention model included metformin 500mg twice daily and a placebo once daily for control group. Alternatively, Vitamin C chewable tablets were given for the other group along with metformin 500mg twice daily. Our study postulates that there is a significant reduction in the fasting blood glucose, glycosylated haemoglobin levels, troponin T levels and Framingham risk score in participants who received ascorbic acid supplementation along with regular metformin. The supplementation of Vitamin C along with Metformin was well tolerated and did not cause any serious adverse drug reactions. The cheaper cost adjuvant approach with Vitamin C may be beneficial in patients in reducing the cardiovascular risk as well as to maintain an appropriate glycaemic control KEYWORDS: Diabetes Mellitus; ascorbic acid; glycemic control; cardiovascular risk.
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