Marmara Pharmaceutical Journal of Research in Pharmacy Journal of Research in Pharmacy 2020 , Vol 24 Issue 4

Title	Marmara Pharmaceutical Journal of Research in Pharmacy Journal of Research in Pharmacy 2020 , Vol 24 Issue 4
Edition	Vol 24 Issue 4
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GMD	Karya Tulis Ilmiah
Language	Indonesia
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Abstract/Notes	ABSTRACT: A series of new 1,3,4-oxadizole derivatives containing thioether group, has been synthesized to investigate their mPGES-1 inhibitory activities. The synthesized compounds were also evaluated for their anticancer and COX-1/2 inhibitory activities. All compounds were checked for their purity using TLC and HPLC analyses. The melting points, elemental analysis, FT-IR, 1H-/13C-NMR and LR-MS data were utilized for structural characterization. The most potent derivative was 2-[5-{[2-methyl-5-(propan-2-yl)phenoxy]methyl}-1,3,4-oxadiazol-2-yl)sulphanyl]-1- (phenyl)ethan-1-one 3a, which showed inhibitory activity against mPGES-1 with an IC50 of 4.95 μM. Docking studies with mPGES-1 and COX-1/2 enzymes revealed their affinity and potential binding mechanism for the tested compounds. KEYWORDS: 1,3,4-Oxadiazoles; thioethers; mPGES-1 inhibition; COX-1/2 inhibition; anticancer activity; molecular docking; ADME prediction.
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