mixed material bibliography monographic Vol 24 Issue 6 id Indonesia

Karya Tulis Ilmiah

ABSTRACT: A series of novel Schiff bases were designed and synthesized by the condensation of 1,3,4-thiadiazoles that contain aromatic primary amine and variously substituted benzaldehydes. The synthesized compounds were screened for their antituberculosis activity against Mycobacterium tuberculosis H37Rv using BACTEC 460 radiometric system. Among the tested compounds, 2-(4-nitrophenyl)amino-5-[4-(3-(4-phenoxy))benzylideneaminophenyl]-1,3,4- thiadiazole (3n) showed the highest inhibitory activity (80%). The activities of the newly synthesized Schiff bases were higher in comparison to those of intermediate products 2-(4-aminophenyl)-5-aryl/alkylamino-1,3,4- thiadiazoles (2a-l). The computational studies were also performed to estimate drug-like profile of the compounds by using QikProp analysis. KEYWORDS: Schiff bases; 1,3,4-thiadiazoles; antituberculosis activity; Mycobacterium tuberculosis H37Rv; ADME. PERPUSTAKAAN SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA REPOSITORY JIN0086 Perpus.Akfarsam (jurnal Internasioan) 615 MAR b Marmara Pharmaceutical Journal of Research in Pharmacy Journal of Research in Pharmacy 2020 , Vol 24 Issue 6 1622 2022-07-20 10:29:02 2022-07-20 10:40:57 machine generated