Journal Of Tropical Pharmacy and Cemistry Vol. 5 No. 3 Januari-Juni (2021)

Title	Journal Of Tropical Pharmacy and Cemistry Vol. 5 No. 3 Januari-Juni (2021)
Edition	Vol. 5 No. 3 Januari-Juni (2021)
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ISBN/ISSN
Author(s)	Fakultas Farmasi Unmul - Personal Name
Subject(s)	farmasi
Classification
Series Title
GMD	Karya Tulis Ilmiah
Language	Indonesia
Publisher	Universitas Mulawarman
Publishing Year	2021
Publishing Place	Samarinda
Collation
Abstract/Notes	Abstract The genus Eucalyptus has been used in African traditional medicine for the treatment of cardiovascular diseases and diabetes. In this work, chloroform and methanol extracts from the leaves of Eucalyptus citriodora was investigated for their phytochemicals, cytotoxicity and antioxidant potentials. Phytochemical screening of the extracts showed the presence of alkaloids, flavonoids, phenols, reducing sugar and steroids in the methanol extract, while the chloroform extract presence of these phytochemicals was observed with exception of reducing sugar. IR absorptions of the extract supported the presence of these phytochemicals by revealing the bands 3335 cm-1 (O-H), 1613, 1480 cm-1 (C=C) and 1721 cm-1 (C=O). Evaluation of the cytotoxicity of the methanol extract using brine shrimp assay, suggested that, the extract was not toxic with LC50 value of 1.64 mg/mL. Antioxidant potentials of both chloroform and methanol extracts were determined using phenolic content quantification and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging. Methanol extract (37.32 μg TAE/mg) had higher phenolic content than the chloroform extract (12.09 μg TAE/mg). The radical scavenging potentials of the extracts recorded percent inhibitions (1000 μg/mL) of 51.33%, 93.05%, 94.43% and 97.80% for chloroform extract, methanol extract, butylated hydroxytoluene and ascorbic acid, respectively. These results showed that E. citriodora might contain promising antioxidant agents. Keywords: Eucalyptus, phytochemicals, brine shrimp, antioxidant
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