Journal Of Tropical Pharmacy and Cemistry Vol 4 no 6 Juli-Desember 2019

Title	Journal Of Tropical Pharmacy and Cemistry Vol 4 no 6 Juli-Desember 2019
Edition	Vol 4 no 6 Juli-Desember 2019
Call Number
ISBN/ISSN
Author(s)	Fakultas Farmasi Unmul - Personal Name
Subject(s)	farmasi
Classification
Series Title
GMD	Karya Tulis Ilmiah
Language	Indonesia
Publisher	Universitas Mulawarman
Publishing Year	2019
Publishing Place	Samarinda
Collation
Abstract/Notes	ABSTRACT Phytoestrogen is a group of compounds that can replace the estrogen function in the body. One of its roles was as anti-neuroinflammatory by inhibiting the microglia M1 polarity activation. Marsilea crenata Presl. is a plant that suspected to contain phytoestrogens. The aim of this research was to determine the metabolite profile of 96% ethanol extract of M. crenata using UPLC-QToF-MS/MS, and prediction the anti-neuroinflammatory activity of compounds with molecular docking. The 100 ppm of 96% ethanol extract in DCM and methanol were injected 5 μl each into the UPLC-QToF-MS/MS, and then analyzed by Masslynx 4.1 software to determine the compounds. The result of metabolite profiling shows a total 59 compounds in both DCM and methanol. Molecular docking was done with Autodock 4.2.6. After being analyzed, there are 3 compounds that are predicted to have activities similar to 17β-estradiol, they are prochlorperazine, 12-Aminododecanoic acid, and 1-methyl-2-[(4-methylpiperazin-1-yl)methyl]benzimidaol-5-amine hydrochloride. The results showed that the three compounds were predicted to be phytoestrogen compounds from M. crenata leaves, which have potential as anti-neuroinflammatory. Keywords: Phytoestrogens, M. crenata, metabolite profiling, anti-neuroinflammatory, in silico
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