Journal Of Tropical Pharmacy and Cemistry Vol 4 no 5 Januari-Juni 2019

Title	Journal Of Tropical Pharmacy and Cemistry Vol 4 no 5 Januari-Juni 2019
Edition	Vol 4 no 5 Januari-Juni 2019
Call Number
ISBN/ISSN
Author(s)	Fakultas Farmasi Unmul - Personal Name
Subject(s)	farmasi
Classification
Series Title
GMD	Karya Tulis Ilmiah
Language	Indonesia
Publisher	Universitas Mulawarman
Publishing Year	2019
Publishing Place	Samarinda
Collation
Abstract/Notes	ABSTRACT Tuberculosis is a disease that attacks the lungs. The disease is caused by the bacterium Mycobacterium tuberculosis. The bacteria M. tuberculosis can be killed by antibiotics. However, continuous use of antibiotics can cause bacterial resistance. This study aims to determine the antibacterial activity of MDR TB from soft coral symbiont bacteria Lobophytum sp. The sample was collected and identification for colony morphology. An antibacterial preliminary test is conducting using the overlay method. Secondary metabolites extraction from bacterial was assayed for antibacterial activity. Bacterial symbiont was conducted for genomic DNA for molecular identification. There were six bacterial isolates obtained from soft coral Lobophytum sp. One isolate from Lobophytum-associated bacteria was successfully screened for antimycobacterial against MDR TB bacteria. PLO2 was found to inhibit the growth of MDR TB (MDR TB strain SIRE and R). Based on the results of identification with PCR, soft coral symbionts of PLO2 was closely related to Virgibacillus marismortui with homology of 99%. Keywords: bacterial symbiont, Lobophytum sp., MDR TB, Virgibacillus marismortui
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