Fakultas Farmasi Unmul Primary Author mixed material bibliography Samarinda Universitas Mulawarman 2019 monographic Vol 4 no 5 Januari-Juni 2019 id Indonesia

Karya Tulis Ilmiah

ABSTRACT Tuberculosis is a disease that attacks the lungs. The disease is caused by the bacterium Mycobacterium tuberculosis. The bacteria M. tuberculosis can be killed by antibiotics. However, continuous use of antibiotics can cause bacterial resistance. This study aims to determine the antibacterial activity of MDR TB from soft coral symbiont bacteria Lobophytum sp. The sample was collected and identification for colony morphology. An antibacterial preliminary test is conducting using the overlay method. Secondary metabolites extraction from bacterial was assayed for antibacterial activity. Bacterial symbiont was conducted for genomic DNA for molecular identification. There were six bacterial isolates obtained from soft coral Lobophytum sp. One isolate from Lobophytum-associated bacteria was successfully screened for antimycobacterial against MDR TB bacteria. PLO2 was found to inhibit the growth of MDR TB (MDR TB strain SIRE and R). Based on the results of identification with PCR, soft coral symbionts of PLO2 was closely related to Virgibacillus marismortui with homology of 99%. Keywords: bacterial symbiont, Lobophytum sp., MDR TB, Virgibacillus marismortui farmasi PERPUSTAKAAN SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA REPOSITORY JN0140 Perpus.Akfarsam 051 FAK j Journal Of Tropical Pharmacy and Cemistry Vol 4 no 5 Januari-Juni 2019 1539 2022-03-18 09:14:02 2022-03-18 09:18:14 machine generated