Indonesia J.Pharm Primary Author mixed material bibliography Jogjakarta Universitas Gadjah Mada 2020 monographic Vol 31 no 3 Juli-September 2020 id Indonesia

Karya Tulis Ilmiah

ABSTRACT Submitted: 07-06-2020 Revised: 30-07-2020 Accepted: 01-07-2020 *Corresponding author Ismiarni Komala Email: ikomala@uinjkt.ac.id Ethyl p-methoxycinnamate (EPMC) (1) is a major natural ester found in the rhizome of Kaempferia galanga and has been reported to have anti- inflammatory activity. Some of the structural modification of this compound has been carried out in order to study the structure-activity relationship on its anti-inflammatory activity. In the present study, we report a new, simple and efficient procedure in the conversion of the ethyl p-methoxycinnamate into N,N-dimethyl-p-methoxycinnamamide (5) and then study the structure- activity relationship on its anti-inflammatory activity. The reaction was carried out through a microwave-assisted direct amidation between (EPMC) (1) with dimethylformamide (DMF) in the basic condition. The mixture was irradiated by using unmodified microwave-oven at 300 W for 1 minute to obtain compound (5) in 88.8% yields. The extensive analysis of the GCMS and NMR data supported that the product of synthesis is N,N-dimethyl-p- methoxycinnamamide (5). Evaluation of the anti-inflammatory activity of compound 5 by using anti-denaturation of heat bovine serum albumin (BSA) assay indicated that N,N-dimethyl-p-methoxycinnamamide (5) still have anti-denaturation activity. Compound 5 has an amide functional group which is more slowly hydrolyzed if compared to 1. Hence, the reaction has successfully produced a more stable compound which still has anti- inflammatory activity Keywords: Anti-inflammatory, direct amidation, N,N-dimethyl-p- methoxycinnamamide, ethyl p-methoxycinnamate, Kaempferia galanga, microwave-promoted synthesis, farmasi PERPUSTAKAAN SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA REPOSITORY JN0131 Perpus.Akfarsam (Jurnal Nasional) 051 MOR j Indonesia Journal of Pharmacy Vol 31 no 3 Juli-September 2020 1503 2022-03-17 10:48:35 2022-03-25 10:23:56 machine generated