Indonesia Journal of Pharmacy Vol 30 no 2 April-Juni 2019

Title	Indonesia Journal of Pharmacy Vol 30 no 2 April-Juni 2019
Edition	Vol 30 no 2 April-Juni 2019
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ISBN/ISSN
Author(s)	Indonesia J.Pharm - Personal Name
Subject(s)	farmasi
Classification
Series Title
GMD	Karya Tulis Ilmiah
Language	Indonesia
Publisher	Universitas Gadjah Mada
Publishing Year	2019
Publishing Place	Jogjakarta
Collation
Abstract/Notes	The present study aims to investigate the neurochemical and behavioral effects of alcohol withdrawal (AW) syndrome in rats. Serotonergic antidepressants such as Citalopram and tianeptine at a dose of 20mg/ kg were tested separately for their ability to prevent seizures in AW groups of rats. Brain regional tryptophan (TRP), 5-hydroxytryptamine (5-HT; serotonin), 5-hydroxyindoleacetic acid (5-HIAA) concentrations were determined using high-performance liquid chromatography connected to the fluorimetric detector. Data analyzed showed increases brain TRP concentrations in all the three regions (amygdala, hippocampus and hypothalamus) after citalopram administered alcohol withdrawn rats; however, tianeptine increases brain TRP concentrations only in amygdala and hippocampus. Increases in brain serotonin concentrations were seen in all the regions only in citalopram administered alcohol withdrawn rats. Further, tianeptine was shown to increase 5-HT turnover in all the regions, however, citalopram appeared to increase 5-HT turnover only in the hippocampus. It is concluded that the citalopram and tianeptine behave differently on the intrinsic pathway of serotonin metabolism that appeared to be compensated by the pattern of 5-HT release. Further, it could be inferred that exposure of serotonergic agents might restore serotonin reuptake mechanism that is desensitized following chronic alcohol exposure. Thus the inclusive approach of the serotonergic system plays an undoubted role in the pharmacological management of AW syndrome. Keywords: Serotonin, antidepressants, tryptophan, tianeptine, citalopram
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