Indonesia Journal of Pharmacy Vol 29 no 2 April-Juni 2018

Title	Indonesia Journal of Pharmacy Vol 29 no 2 April-Juni 2018
Edition	Vol 29 no 2 April-Juni 2018
Call Number
ISBN/ISSN
Author(s)	Indonesia J.Pharm - Personal Name
Subject(s)	farmasi
Classification
Series Title
GMD	Karya Tulis Ilmiah
Language	Indonesia
Publisher	Universitas Gadjah Mada
Publishing Year	2018
Publishing Place	Jogjakarta
Collation
Abstract/Notes	ABSTRACT A suitable matrix system of ketorolac tromethamine (KTR) formulation has been developed with the aim of increasing the contact time, achieving controlled release, reducing the frequency of administration, improving patient compliance. In this concern an enteric-coated KTR matrix tablet intended for specific delivery of drugs to the colon by combining the use of a time dependent core with a pH-sensitive film coating. Eudragit L100, with a threshold pH 7, was selected as coating material. New formulation is proved to be noble as to KTR delivery through both gastrointestinal and colonic system. New formulation is considered to reduce gastrointestinal side effects and achieve high local drug concentration at the afflicted site in the gastro- intestine and colon. Key words: Drug Formulation, Ketorolactromethamine, gastrointestinal and colonic delivery system, HPLC analysis
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