Indonesia J.Pharm Primary Author mixed material bibliography Jogjakarta Universitas Gadjah Mada 2018 monographic Vol 29 no 2 April-Juni 2018 id Indonesia

Karya Tulis Ilmiah

ABSTRACT A suitable matrix system of ketorolac tromethamine (KTR) formulation has been developed with the aim of increasing the contact time, achieving controlled release, reducing the frequency of administration, improving patient compliance. In this concern an enteric-coated KTR matrix tablet intended for specific delivery of drugs to the colon by combining the use of a time dependent core with a pH-sensitive film coating. Eudragit L100, with a threshold pH 7, was selected as coating material. New formulation is proved to be noble as to KTR delivery through both gastrointestinal and colonic system. New formulation is considered to reduce gastrointestinal side effects and achieve high local drug concentration at the afflicted site in the gastro- intestine and colon. Key words: Drug Formulation, Ketorolactromethamine, gastrointestinal and colonic delivery system, HPLC analysis farmasi PERPUSTAKAAN SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA REPOSITORY JN0122 Perpus.Akfarsam (Jurnal Nasional) 051 MOR j Indonesia Journal of Pharmacy Vol 29 no 2 April-Juni 2018 1493 2022-03-17 09:21:03 2022-03-25 10:08:46 machine generated