Indonesia Journal of Pharmacy Vol 27 no 4 Agustus-Desember 2016

Title	Indonesia Journal of Pharmacy Vol 27 no 4 Agustus-Desember 2016
Edition	Vol 27 no 4 Agustus-Desember 2016
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ISBN/ISSN
Author(s)	Indonesia J.Pharm - Personal Name
Subject(s)	farmasi
Classification
Series Title
GMD	Karya Tulis Ilmiah
Language	Indonesia
Publisher	Universitas Gadjah Mada
Publishing Year	2016
Publishing Place	Jogjakarta
Collation
Abstract/Notes	ABSTRACT Several novel 2-[(substitutedphenyl)-5-(1-phenyl-3- (piperazinyl) pyrido[3,2-f] quinazolin-4(1H)-yl]-1,3,4 thiadiazole derivatives have been designed and synthesised by incorporating four known moieties suchas 2-methylquinolin-5-ol, acetophenone, urea and 3-substitutedphenyl-4-amino-5-mercapto triazoles by using multi-step conventional reaction strategy. The synthesized derivatives were characterized by IR, 1H-NMR, Mass and elemental analysis (C, H, N). Furthermore the synthesized 2-[(substitutedphenyl)-5-(1-phenyl-3-(piperazinyl)pyrido[3,2-f] quinazolin-4(1H)-yl]-1,3,4-thiadiazoles 4a-g were screened for antibacterial and antifungal activities. The bacterial panel consisted of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris while fungal panel included of Aspergillus fumigatus (plant isolate), Candida glabrata, Candida albicans, Candida krusei. Ampicillin trihydrate and fluconazole were used as reference drugs for antibacterial and antifungal activity, respectively. Bacterial and fungal inhibition determined by disk diffusion and serial plates dilution method, respectively. Pathogenic inhibitions were determined by measuring the diameter of the inhibition zone in mm. Compound 4c demonstrated significant antibacterial and antifungal spectrum against all the tested microbes. Keywords- antibacterial, antifungal and substituted 1,3,4-thiadiazoles
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