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Title |
Marmara Pharmaceutical Journal of Research in Pharmacy Journal of Research in Pharmacy 2020 , Vol 24 Issue 3 |
Edition |
Vol 24 Issue 3 |
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Series Title |
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GMD |
Karya Tulis Ilmiah |
Language |
Indonesia |
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Abstract/Notes |
ABSTRACT: Tramadol hydrochloride/paracetamol is an opioid that is composed of two different analgesics, tramadol
(opioid, 37.5 mg) and paracetamol (non opioid, 325 mg). The study presents first data of tramadol
hydrochloride/paracetamol effects on haematological parameters and glucose levels in Wistar rats. Oral administration
ad libitum of tramadol hydrochloride/paracetamol was administered during a twenty days period. This research
includes two groups of animals. Group I include animals that were administered tramadol hydrochloride/paracetamol
daily at dosage of 1.12 g/300 ml and group II that were administered daily at dosage of 1.68 g/300 ml of water. We
analayzed 14 haematological parameters and glucose concentration. Significant changes were established for all
analyzed parameters. Significantly low numbers of erythrocytes, leukocytes and lymphocytes were observed. Tramadol
hydrochloride/paracetamol has an extremely negative effect on haematological parameters in Wistar rats, particularily
on the blood coagulation due to the thrombocitopenia, anaemia and weakened immunity. If properly administered,
tramadol hydrochloride/paracetamol can be an effective analgesic but at high dosage and over a prolonged period it
may cause adverse effects in Wistar rats.
KEYWORDS: Tramadol hydrochloride/paracetamol; Wistar rats; haematological parameters; glucose. |
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