Marmara Pharmaceutical Journal of Research in Pharmacy Journal of Research in Pharmacy 2021 , Vol 25 Issue 1

Title	Marmara Pharmaceutical Journal of Research in Pharmacy Journal of Research in Pharmacy 2021 , Vol 25 Issue 1
Edition	Vol 25 Issue 1
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GMD	Karya Tulis Ilmiah
Language	Indonesia
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Abstract/Notes	ABSTRACT: This study aimed to assess the potential usage of fusidic acid in situ ocular gels for bacterial conjunctivitis treatment. The in situ gelling systems were applied to improve the bioavailability and residence time of fusidic acid in the ocular mucosa. Temperature-triggered in situ ocular gel formulations were prepared by the cold method with Poloxamer 407 and sodium carboxymethyl cellulose. The in situ gels were evaluated for pH, clarity, gelation temperature, rheological properties, mechanical properties, and in vitro drug release. The gelation temperatures of fusidic acid loaded the formulations were between 29–33°C. All prepared in situ gels showed non- Newtonian pseudoplastic flow (shear thinning system) like tear fluid at 32 ± 0.1oC. The results of in vitro dissolution studies showed that at least 65% of fusidic acid released in 12 hours. As a result of this study, it was concluded that fusidic acid loaded in situ gels might be offered as a promising ocular tool for the treatment of bacterial conjunctivitis. KEYWORDS: Fusidic acid; in situ gel; poloxamer; NaCMC; ocular.
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