Indonesia Journal of Pharmacy Vol 34 No 1 2023

Title	Indonesia Journal of Pharmacy Vol 34 No 1 2023
Edition	Vol 34 No 1 2023
Call Number
ISBN/ISSN
Author(s)
Subject(s)	Antimicrobial resistance gene transfer biofilm formation bacterial infection
Classification
Series Title
GMD	Karya Tulis Ilmiah
Language	Indonesia
Publisher	Universitas Gadjah Mada
Publishing Year	2022
Publishing Place	Jogjakarta
Collation
Abstract/Notes	In this review, we describe the known mechanisms of antimicrobial resistance which was increasing in this era, due to the misuse of antimicrobial agents such as antibiotics, or genetic and phenotypic mechanisms. The special concerns addressed by designated researchers in their study and WHO in their observations and reports, regarding the types or strains of bacteria with antimicrobial resistances, were described. In addition, the predicted mechanisms that promote the development and occurrence of antimicrobial resistance, such as bacterial biofilm formation, horizontal gene transfer, genetic mutations, free DNA which contains antimicrobial resistance genes, and plasmids transfer through transformation or conjugation from bacterial cell to cell were well described. In addition, we also tried to describe the use of Z. officinale. The antimicrobial capabilities of this herbal plant are attributed to its capacity to create many secondary metabolites with rather complicated structures that have antibacterial and antioxidant characteristics. Z. officinale had been used for many kinds of disease treatment traditionally. And along the way, the advance techniques of research in chemistry and biology fields had found out the composition and bioactive compounds. The common online databases such as PubMed, Semantic Scholar, Crossref, Medline, Scopus, and Web of Science (WoS) were utilized in this review to conduct literature searches. According to the recent progress of antimicrobial cases observed, the efforts to strengthen the surveillance, and general health systems, tightened the antimicrobial medicine distribution rules, and education for the public are indeed needed. Key words: Antimicrobial resistance, gene transfer, biofilm formation, bacterial infection, Zingiber officinale
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